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D H A R A

GI ALLY

GI ALLY

$89.50 USD
$89.50 USD
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GI ALLY was uniquely formulated to promote microbiome balance in both the small and large intestine*

Allicin (Allisure AC-23®) -  Pomegranate hull - Neem leaf 

Potential benefits may include:

  • Overall gut health and digestive balance*
  • Decreased bloating, gas and abdominal discomfort*
  • Improved regularity*
  • Increased nutrient absorption*
  • Support of cardiovascular, immune and skin health*

GI ALLY contains three herbs traditionally used to support those struggling with SIBO and Intestinal Methanogen Overgrowth.* The transparent dosing was intentionally selected by a Naturopathic Doctor and Pharmacist, and formulated in a vegan capsule without fillers. 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Information and statements are not intended to replace the advice of your treating doctor, and are not intended to be a substitute for conventional medical service.  
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Supplement Facts

Serving size: 2 capsules    Servings per container: 45

Amount per serving:

Allicin extract (garlic bulb) (Allisure® AC-23)                  450mg                               **

Neem leaf (Azadirachta indica)                                           300mg                               **

Pomegranate hull extract (Punica granatum L.)             240mg                               **

**Daily values not established

Other ingredients: vegetable capsule (hydroxypropyl methylcellulose)

Formulated without gluten, dairy, soy, yeast, GMOs, or fillers. Vegan and gut friendly. Made in the USA in a cGMP compliant, FDA registered facility.

Suggested Use

Reset: 1-2 capsules three times a day for 4-6 weeks, or as recommended by your healthcare practitioner.

Maintenance: 1 capsule 1-2 times a day or as recommended by healthcare practitioner.

Warnings

Warning: Do not use if you are pregnant, nursing or actively trying to conceive. Consult your healthcare practitioner prior to use. Use only if bottle is sealed. Keep out of reach of children. Store tightly sealed in a cool, dry place out of direct sunlight.

Allergen Warning: Made in a facility that may also process products containing Milk, Eggs, Fish, Shellfish, Tree Nuts, Peanuts, Wheat, Soybeans, and/or Sesame.

CA Prop 65: This product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov

Allicin

  • 100% Allisure® AC-23, a patented, stabilized extract from Spanish garlic that includes the benefits of garlic, without the bloat
  • A loved and trusted ingredient by SIBO/IMO practitioners worldwide, used traditionally to help support those with intestinal methanogen overgrowth, and for its antifungal, antibacterial, antiviral and anti-biofilm properties* [1][2][5][6].
  • Antibacterial properties: Allicin has demonstrated potent activity against pathogens such as Escherichia coli (E. coli), Klebsiella, Staphylococcus, Streptococcus and Clostridium, including antibiotic-resistant strains* [1][2][9]. 
  • Antifungal properties: Allicin has demonstrated activity against various fungal species, including Candida albicans, as well as inhibiting the formation of mycotoxins such as aflatoxin from Aspergillus [1][2][5].
  • Cardiovascular health: Promotes cardiovascular health through the potential to lower blood pressure, reduce cholesterol levels and inhibit platelet aggregation*[3][4].
  • Immune support: Supports healthy immune function by enhancing and regulating the activity of certain immune cells and improving defense against infections.*[7][8]

Pomegranate

  • Pomegranate is a beloved staple of the Mediterranean diet, and for good reason! But have you ever been told that the greatest benefit may actually come from the skin?
  • Pomegranate skin is traditionally used in Australia and New Zealand to help support those suffering from SIBO*
  • Antioxidant & Anti-inflammatory: Pomegranate skin contains polyphenols (pulicalagin and punicalagin), flavonoids, anthocyanadins, and other compounds that have been shown to have antioxidant and anti-inflammatory properties systemically, and specifically in the cells and tissues of the GI tract.* [10][11]
  • Antimicrobial properties: Pomegranate skin contains potent tannins, including ellagitannins, gallotannins and other compounds that traditionally have been used for their antibacterial, antifungal, and antiparasitic properties against organisms such as E.coli, klebsiella, streptococcus, enterococcus faecalis, and candida albicans* [10][12][14]
  • Dermatological benefits: Studies suggest that pomegranate skin may improve your skin, including conditions ranging from hyperpigmentation and acne, to UVB protection and anti-aging benefits such as stimulating type I collagen production* [13][15]
  • Cardiovascular health: Pomegranate skin may support cardiovascular health by promoting healthy glucose and insulin levels, as well as decreasing LDL cholesterol and increasing HDL cholesterol* [16]

Neem

  • Neem has been used for centuries in Ayurvedic medicine for its health promoting benefits. In fact, its sanskrit name, Arishtha, means “reliever of sickness”*[17]
  • Used traditionally to support those suffering from SIBO and fungal overgrowth*
  • Antibacterial: Contains a variety of compounds, including flavonoids, tannins, triterpenoids and limonoids, which have been used traditionally for their antimicrobial properties, against organisms such as E. coli, S. aureus, Pseudomonas aeruginosa, and Bacillus subtilis, including activity against drug resistant and and biofilm-forming organisms* [18][19]
  • Antifungal & Antiparasitic: increased antifungal activity against both candida albicans and candida tropicalis, and antiparasitic activity against organisms such as Trypanosoma cruzi*  [18][19][20]
  • Dental benefits: used traditionally in oral hygiene products to reduce gum inflammation and periodontal disease* [20]
  • Dermatological benefits: Through astringent, anti-inflammatory, and gentle detoxification properties, neem leaf may also promote glowing skin, hair growth, and strong nails* [18][20]

Research & Citations

A note on research and citations:

We have included a variety of references based on currently available publications for the individual ingredients and herbal constituents. Of note, the majority of the included studies are in vitro studies, older studies, or review papers. None of these studies are on our individual product. We hope these are informative resources, while also recognizing and encouraging the careful analysis and appraisal of the literature. These references should be appreciated in that context, and are not intended as claims.

(1) Choo S, Chin VK, Wong EH, Madhavan P, Tay ST, Yong PVC, Chong PP. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol (Praha). 2020 Jun;65(3):451-465. doi: 10.1007/s12223-020-00786-5. Epub 2020 Mar 23. PMID: 32207097.

(2) Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999 Feb;1(2):125-9. doi: 10.1016/s1286-4579(99)80003-3. PMID: 10594976.

(3) Ried K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014 Dec 9;7:71-82. doi: 10.2147/IBPC.S51434. PMID: 25525386; PMCID: PMC4266250.

(4) Sobenin IA, Andrianova IV, Demidova ON, Gorchakova T, Orekhov AN. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. J Atheroscler Thromb. 2008 Dec;15(6):334-8. doi: 10.5551/jat.e550. Epub 2008 Dec 6. PMID: 19060427.

(5) Patil BS, Jayaprakasha GK, Chidambara Murthy KN, Vikram A. Bioactive compounds: historical perspectives, opportunities, and challenges. J Agric Food Chem. 2009 Sep 23;57(18):8142-60. doi: 10.1021/jf9000132. PMID: 19719126.

(6) Ranjbar-Omid M, Arzanlou M, Amani M, Shokri Al-Hashem SK, Amir Mozafari N, Peeri Doghaheh H. Allicin from garlic inhibits the biofilm formation and urease activity of Proteus mirabilis in vitro. FEMS Microbiol Lett. 2015 May;362(9):fnv049. doi: 10.1093/femsle/fnv049. Epub 2015 Apr 2. PMID: 25837813.

(7) Harris JC, Cottrell SL, Plummer S, Lloyd D. Antimicrobial properties of Allium sativum (garlic). Appl Microbiol Biotechnol. 2001 Oct;57(3):282-6. doi: 10.1007/s002530100722. PMID: 11759674.

(8) Dirsch, V. M., Kiemer, A. K., & Wagner, H. (1998). Garlic and allicin: The versatile Alliums. Trends in Pharmacological Sciences, 19(8), 309-313.

(9) Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014 Jan;4(1):1-14. PMID: 25050296; PMCID: PMC4103721. 

(10) Akhtar S, Ismail T, Fraternale D, Sestili P. Pomegranate peel and peel extracts: chemistry and food features. Food Chem. 2015 May 1;174:417-25. doi: 10.1016/j.foodchem.2014.11.035. Epub 2014 Nov 15. PMID: 25529700.

(11) Mastrogiovanni F, Mukhopadhya A, Lacetera N, Ryan MT, Romani A, Bernini R, Sweeney T. Anti-Inflammatory Effects of Pomegranate Peel Extracts on In Vitro Human Intestinal Caco-2 Cells and Ex Vivo Porcine Colonic Tissue Explants. Nutrients. 2019 Mar 5;11(3):548. doi: 10.3390/nu11030548. PMID: 30841512; PMCID: PMC6471410.

(12) Al-Zoreky NS. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int J Food Microbiol. 2009 Sep 15;134(3):244-8. doi: 10.1016/j.ijfoodmicro.2009.07.002. Epub 2009 Jul 12. PMID: 19632734.

(13) Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006 Feb 20;103(3):311-8. doi: 10.1016/j.jep.2005.07.027. Epub 2005 Oct 10. PMID: 16221534. 

(14) Barathikannan K, Venkatadri B, Khusro A, Al-Dhabi NA, Agastian P, Arasu MV, Choi HS, Kim YO. Chemical analysis of Punica granatum fruit peel and its in vitro and in vivo biological properties. BMC Complement Altern Med. 2016 Jul 30;16:264. doi: 10.1186/s12906-016-1237-3. PMID: 27476116; PMCID: PMC4967515.

(15) Binic I, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D. Skin ageing: natural weapons and strategies. Evid Based Complement Alternat Med. 2013;2013:827248. doi: 10.1155/2013/827248. Epub 2013 Jan 29. PMID: 23431351; PMCID: PMC3569896.

(16) Hosseini B, Saedisomeolia A, Wood LG, Yaseri M, Tavasoli S. Effects of pomegranate extract supplementation on inflammation in overweight and obese individuals: A randomized controlled clinical trial. Complement Ther Clin Pract. 2016 Feb;22:44-50. doi: 10.1016/j.ctcp.2015.12.003. Epub 2015 Dec 12. PMID: 26850805.

(17) Biswas, K., Chattopadhyay, I., Banerjee, R. K., & Bandyopadhyay, U. (2002). Biological activities and medicinal properties of neem (Azadirachta indica). Current Science, 82(11), 1336–1345. http://www.jstor.org/stable/24106000

(18) Gupta SC, Prasad S, Tyagi AK, Kunnumakkara AB, Aggarwal BB. Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. Phytomedicine. 2017 Oct 15;34:14-20. doi: 10.1016/j.phymed.2017.07.001. Epub 2017 Jul 3. PMID: 28899496.

(19) Sarkar P, Acharyya S, Banerjee A, Patra A, Thankamani K, Koley H, Bag PK. Intracellular, biofilm-inhibitory and membrane-damaging activities of nimbolide isolated from Azadirachta indica A. Juss (Meliaceae) against meticillin-resistant Staphylococcus aureus. J Med Microbiol. 2016 Oct;65(10):1205-1214. doi: 10.1099/jmm.0.000343. Epub 2016 Aug 23. PMID: 27553840.

(20) National Research Council (US) Panel on Neem. Neem: A Tree For Solving Global Problems. Washington (DC): National Academies Press (US); 1992. 7, Medicinals. Available from:https://www.ncbi.nlm.nih.gov/books/NBK234637/